The airway smooth muscle cell: a major contributor to asthma?
نویسندگان
چکیده
منابع مشابه
The airway smooth muscle cell: a major contributor to asthma?
Since REISSEISEN [1] first described the airway smooth muscle (ASM) of the bronchial tree extending from the central airways to the level of the membranous bronchiole in 1822, ignorance of the physiological function of this prominent component of the airways in health and disease has continued. The above question will surely be answered one day, when a model of conducting airways devoid of ASM ...
متن کاملAirway smooth muscle and asthma.
The airway smooth muscle is the key determinant of airway narrowing in asthma but its function in the absence of disease is unknown. Evidence for an intrinsic abnormality in the muscle in asthma is only just emerging. The airway smooth muscle is not merely a contractile cell, but also one which determines the composition of, and interacts with the extracellular matrix, and which may participate...
متن کاملInflammation signals airway smooth muscle cell proliferation in asthma pathogenesis
UNLABELLED BACKGROUND Airway inflammation stimulates proliferation of airway smooth muscle cell, which contributes to the development of hyperplasia and hypertrophy of smooth muscle cell. The increase in airway smooth muscle cell mass is believed to be due to an up-regulation of inflammatory mediators in the airway. It is now well recognized that chronic inflammation as well as airway hyper-...
متن کاملMast cell regulation of airway smooth muscle function in asthma.
A sthma is a common disease affecting f10% of the adult Western population [1, 2]. It is characterised by the presence of variable and potentially reversible airflow obstruction, which occurs as the result of bronchoconstriction, airway mucus plugging and airway oedema. Pathologically there is evidence of airway inflammation and remodelling [3– 7]. The mucosal inflammatory infiltrate commonly c...
متن کاملAirway Smooth Muscle Hypercontractility in Asthma
In recent years, asthma has been defined primarily as an inflammatory disorder with emphasis on inflammation being the principle underlying pathophysiological characteristic driving airway obstruction and remodelling. Morphological abnormalities of asthmatic airway smooth muscle (ASM), the primary structure responsible for airway obstruction seen in asthma, have long been described, but surpris...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2000
ISSN: 0903-1936,1399-3003
DOI: 10.1034/j.1399-3003.2000.15.02.x